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The toenail should be trimmed to avoid irritation or cuts on the skin of the foot nail central. People should avoid getting their feet hurt, stimulating or bacterial habits, such as walking barefoot or sharing hygiene tools nail central. Those who experience any abnormal, persistent or worrying symptoms should see a doctor nail central. Regular, consistent foot care helps reduce the likelihood of amputation by 45% to 85% nail central. 5 nail central. Commonly used drugs for diabetic neuropathy Over-the-counter painkillers usually help relieve nerve pain nail central. For more serious cases, the doctor may prescribe a more concentrated specific drug. Everyone taking painkillers should be cautious, and people with blood pressure or bleeding should be especially careful. If people have any worrying symptoms, they should go to the doctor. Common drug options for the treatment of diabetic neuropathy include: opioids such as morphine sulfate, tramadol, oxycodone and dextromethorphan antidepressants such as venlafaxine, amitriptyline and duloxetine Hydrochloride anticonvulsants, such as pregabalin and sodium valproate, such as capsaicin cream, isosorbide dinitrate spray and lidocaine patch, some forms of electrical nerve stimulation, such as transcutaneous electrical nerve stimulation (TENS), a diabetic neuropathy approved for the treatment of pain. Although there is some evidence that magnetic therapy, laser and phototherapy are used to reduce or control neuropathic pain, AAN does not currently recommend these therapies. Sixth, diabetic neuropathy complications If no treatment control, diabetic neuropathy may lead to more serious complications. Diabetic neuropathy can prevent wound healing and even cause gangrene in severe cases. Some complications include: pain, stiffness or soreness without realizing hypoglycemia, nausea and vomiting, hunger, impaired diarrhea and constipation, impaired hand, leg and foot infections or wounds that do not heal joint damage, especially foot and leg bladder control Or excessive urinary problems or lack of sweat muscle atrophy gangrene or amputation, the most common is low blood pressure in the foot or leg. 7. Research progress in diabetic neuropathy Researchers continue to investigate the causes and ways of diabetic neuropathy, hoping to develop more precise treatment options. Almost all drug choices used to treat this condition are not actually intended to target neuropathic pain. Most current drugs also have unpleasant side effects and the risk of dependence. Most recent studies of the treatment of diabetic neuropathy have focused on blocking or altering pain signals. A 2013 study confirmed that drug-targeted calcium T-channels can help reduce pain-related addiction or dependence associated with diabetic neuropathy. The 2015 study found that blocking the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel in rats dramatically reduces the perception of pain in areas of the brain that are most frequently involved in the processing of pain signals. Spinal cord simulation (SCS) therapy is also being explored. A 2016 study using rodents found that early, repetitive SCS may be reduced and stimulated by endogenous cannabinoid systems and activated CB1 receptors in reverse neuropathic pain. Drugs that target molecules on the surface of nerve cells, called gangliosides, have long been studied as potential treatments for neurodegenerative diseases, and gangliosides have been shown to affect the brain’s ability to form new neural connections.